What Is DSIP?
DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide neuromodulator studied in preclinical sleep and stress research. It is not an FDA-approved drug.
The short answer
DSIP is a nine-amino-acid peptide (sequence WAGGDASGE) first isolated for its association with delta-wave sleep in early animal studies. It is characterized in research as a neuromodulator, though its literature is older and its mechanisms less resolved than many peptides — a point worth being honest about.
Composition and specifications
| Compound | DSIP (Delta Sleep-Inducing Peptide) |
|---|---|
| Class | Nonapeptide neuromodulator |
| Also known as | CAS 62568-57-4 |
| Sequence / length | Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (WAGGDASGE) |
| CAS number | 62568-57-4 |
| Molecular weight | 848.8 g/mol |
| Purity (typical) | ≥99.0% |
| Appearance | White lyophilized powder; water-soluble |
Values above reflect the compound's published specification. As with any research material, the definitive confirmation of identity and purity for a given lot is the mass-spectrometry and HPLC data on its Certificate of Analysis.
How it is described mechanistically
DSIP is characterized in the research literature as a neuromodulatory peptide associated with sleep regulation and stress-response signaling. Its precise mechanism is not well resolved; findings across studies have been mixed, and it is best described as a peptide of continuing but unsettled research interest.
What has research examined?
Published DSIP work is preclinical and dates back several decades. Areas examined include:
- Sleep-regulation and delta-wave research models
- Stress-response and neuroendocrine signaling
- Circadian and neuromodulatory research
- Analgesia-associated research models
The DSIP literature is older and less consistent than that of many peptides; treat findings as unsettled research directions.
How is it characterized and tested?
Two questions matter most about any peptide sample in a research context: is it the right molecule, and how pure is it. Those are answered by analytical testing — commonly mass spectrometry for identity and HPLC for purity — with both reported on a batch-specific Certificate of Analysis (COA). An independent, published COA lets a researcher confirm identity and purity before beginning work. See peptide handling and storage for how samples are kept stable once received.
Primary literature: browse peer-reviewed studies on DSIP at PubMed.
Common questions
What does DSIP stand for?
Delta Sleep-Inducing Peptide — named for its early association with delta-wave sleep in animal research. It is a nonapeptide (nine amino acids).
Is DSIP approved for human use?
No. DSIP is not an FDA-approved drug. Research-grade material is for laboratory research use only.
Is DSIP's mechanism well understood?
Not fully. Its research literature is older and findings have been mixed, so it is best described as a peptide of unsettled research interest rather than one with a clearly established mechanism.